The role of minor groove functional groups in DNA hydration
نویسندگان
چکیده
منابع مشابه
The role of minor groove functional groups in DNA hydration.
Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2...
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15 صفحه اولRegularities in formation of the spine of hydration in the DNA minor groove and its influence on the DNA structure.
Computer calculations as well as an analysis of space-filling models and literature data allowed the following conclusions to be made: an ordered spine of water in the DNA minor groove, similar to that revealed in the CGCGAATTCGCG crystal, seems to exist in DNA crystals, fibers and solutions; it is shown that this spine may be formed on A/T runs containing no TA step while on the TA step the sp...
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Exocyclic groups in the minor groove of DNA modulate the affinity and positioning of nucleic acids to the histone protein. The addition of exocyclic groups decreases the formation of this protein-DNA complex, while their removal increases nucleosome formation. On the other hand, recent theoretical results show a strong correlation between the B(I)/B(II) phosphate backbone conformation and the h...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2003
ISSN: 1362-4962
DOI: 10.1093/nar/gkg240